Field-Effect Flow Control for 2-D and 3-D Microfluidics

Abstract

Report prepared for the SBIR Phase II contract titled "Field-effect flow control for 2-D and 3-D microfluidics". The SBIR Phase II project reported here proposed to develop technology for Multidimensional Separations and Mass Spectrometry in a Microfiuidic System. This system combines the field-effect flow control technology with a related microfluidic product developed at Calibrant for proteomic analysis, the MicroDisplay2D. The multidimensional separation in a microfluidic platform is designed to enable multianalyte pathogen detection using protein biomarkers for effective, portable, and universal biological warfare agent identification. The work was focused on optimization, integration, and validation of the combined platform. The end goal was to develop a high resolution two-dimensional separation microfluidic platform that could rival 2D-PAGE in capability for producing protein expression maps. The initial target application was to utilize protein expression maps produced from this technology to identify protein biomarkers unique to specific pathogens of concern that can be employed as biological warfare agents.

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Document Details

Document Type
Technical Report
Publication Date
Feb 13, 2006
Accession Number
ADA444406

Entities

People

  • Ponniah Sivanesan

Tags

Communities of Interest

  • Advanced Electronics
  • Weapons Technologies

DTIC Thesaurus Topics

  • Biological Warfare
  • Biological Warfare Agents
  • Contracts
  • Detection
  • Detectors
  • Electric Fields
  • Flow
  • Fluid Flow
  • Gel Electrophoresis
  • High Resolution
  • Hypervelocity Flow
  • Laser Beams
  • Lasers
  • Mass Spectrometry
  • Materials
  • Three Dimensional
  • Two Dimensional

Fields of Study

  • Chemistry

Readers

  • Critical Infrastructure Protection in CBRN and WMD Threats.
  • Integrated Circuit Design and Technology.

Technology Areas

  • Biotechnology