Development and Experimental Verification of Surface Effects in a Fluidic Model
Abstract
Sensor and diagnostic systems based on microfluidic devices have already achieved very low total detection limits which are projected to approach the single molecule level. Under such conditions adverse wall/sample interactions, such as adsorption, could significantly or completely deplete the analyte stream of the material of interest, at total coverage much smaller than a monolayer. Careful understanding of the interaction of flow surface availability and adsorption is required. The research team on this effort carried out experimental determination and verification of flow effects on wall/biomaterial interactions. Results were incorporated into an existing software suite to generate an advanced model of adsorption under flow conditions. The knowledge gained from this effort represents a step forward in providing the proper tools and techniques to successfully simulate microfluidic device and system concepts prior to prototyping.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2006
- Accession Number
- ADA444620
Entities
People
- James J Hickman
- Shankar Sundaram
Organizations
- Clemson University