Targeting Complement in Treatment of Intestinal Ischemia/Reperfusion-Induced Injury

Abstract

Complement activation occurs during tissue injury and inappropriate or excessive activation contributes to the expression of pathology becoming a double-edged sword. Understanding the role of complement and its natural regulatory molecules will enable the development of therapeutic interventions to prevent excessive damage during mesenteric ischemia/reperfusion (IR). In this chapter, we will briefly review the mechanism of complement activation during intestinal ischemia/reperfusion and discuss results and significance of mesenteric ischemia/reperfusion induced injury in animal models with altered complement activation. Finally, we will discuss development of current inhibitors of complement activation and those that may be used in the future.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2004
Accession Number
ADA444624

Entities

People

  • George C. Tsokos
  • Juliann G Kiang
  • Sherry D Fleming

Organizations

  • Walter Reed Army Institute of Research

Tags

DTIC Thesaurus Topics

  • Blood
  • Cardiovascular System
  • Carrier Proteins
  • Cells
  • Combat Casualty Care
  • Diseases And Disorders
  • Ground Based
  • Hemorrhagic Shock
  • Immunoglobulins
  • Inflammation
  • Intestines
  • Molecules
  • Myocardial Ischemia
  • Shock (Pathology)
  • Therapy
  • Vascular Diseases
  • Wounds And Injuries

Fields of Study

  • Biology
  • Medicine

Readers

  • Immunology
  • Immunology and Pathology
  • Joint Military Operations and Doctrine.