Neutralizing Antibody Response to Booster Vaccination with the 17d Yellow Fever Vaccine
Abstract
A retrospective review was conducted of yellow fever vaccination among laboratory workers receiving annual serologic assessment to determine the initial and long-term response after boosting. Patients were divided into three groups based on pre-vaccination serology: Group 1, 1:10; Group 2, 1:20-1:40 and Group 3, >1:40. The percent with >/=four-fold increase in titers after booster vaccination were: 78% (646/829, Group 1), 65% (79/121, Group 2) and 10% (8/79, Group 3) (p<0.0001). The median times to titer failure (<1:40) were 798 days (Group 1), 3340 days (Group 2) and 7709 days (Group 3) (p<0.0001). Pre-vaccination serology influenced the initial and long-term response to yellow fever booster vaccination.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 18, 2006
- Accession Number
- ADA444709
Entities
People
- E. F. Boudreau
- E. L. Anderson
- J. A. Mangiafico
- M. G. Kortepeter
- M. J. Hepburn
- P. A. Buck
- P. R. Pittman
- S. L. Norris
Organizations
- United States Army Medical Research Institute of Infectious Diseases