Detection of Genetic Alterations in Breast Sentinel Lymph Node by Array-CGH
Abstract
The sentinel lymph node (SLN) is the first node in the mammary gland to harbor malignant cells in breast tumors with metastasis, and SLN positivity is an indication for axillary lymph node dissection. The purpose of our study is to identify specific genetic alterations using array-OGH in the metastatic sentinel lymph node lesions, in comparison to the ones observed in the corresponding primary tumors from patients with breast cancer. We believe that the characterization of genetic alterations at the SLN site is a logical step to define the cytogenetic evolution of primary tumors to a metastatic state, and may represent the initial genetic events that occur in the early metastatic process, before distant metastasis occur. Ultimately these alterations can be used as molecular markers that can help in the reduction or elimination of the need for invasive surgical procedures, such as axillary dissection, in the management of breast cancer patients.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2005
- Accession Number
- ADA444833
Entities
People
- Luciane R. Cavalli
Organizations
- Georgetown University