Changes in Interstitial Metabolic Parameters during Hemorrhagic Shock
Abstract
Decompensation in hemorrhagic shock is the critical stage after which resuscitative efforts may prove futile. One mechanism for decompensation may be potassium-mediated vasodilation and/or loss of cardiac contractility, and thus a method of measuring interstitial potassium may be a crucial part of future metabolic monitoring efforts. Anesthetized rats underwent controlled hemorrhage to a constant mean arterial pressure of 40 mmHg. Microdialysis probes were implanted in skeletal muscle, vein, and liver for continuous assessment of potassium, glucose, lactate, pyruvate, and glycerol concentrations. Arterial blood samples were drawn at 30-minute intervals, until late (decompensatory) hemorrhagic shock was reached. Potassium concentrations in muscle interstitium were significantly higher in hemorrhaged animals than controls (2.34 times baseline vs. 1.24, p < 0.05), this difference was not reflected in blood values. These data may provide clues into new ways to monitor and treat victims of hemorrhagic shock on the battlefield.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2004
- Accession Number
- ADA444960
Entities
People
- Elena R. Morris
- James D. Oliver Iii
- James F. Schooley
- James L. Atkins
- Lei Wang
- Motilal B. Pamnani
- Timothy B. Bentley
Organizations
- Walter Reed Army Institute of Research