Complement Inhibitor APT070 Dramatically Reduces the Need for Resuscitation and Improves Survival in Controlled Isobaric Rat Hemorrhage Model

Abstract

The complement system (C) becomes activated during hemorrhagic shock in a rat isobaric hemorrhage model, a process significantly aggravating the outcome of shock. Consequently, inhibition of C activation may have beneficial effects on both survival and metabolic status of animals subjected to shock.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2004
Accession Number
ADA445067

Entities

People

  • Carl R. Alving
  • David Purger
  • Dirk Esser
  • Janos Szebeni
  • Lajos Baranyi
  • Richard D. Smith
  • Timothy B. Bentley

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Anaphylatoxins
  • Arteries
  • Blood
  • Blood Chemistry
  • Cardiovascular Physiological Phenomena
  • Cardiovascular System
  • Casualties
  • Chemistry
  • Combat Casualty Care
  • Ground Based
  • Hemorrhage
  • Hemorrhagic Shock
  • Inhibitors
  • Molecules
  • Shock (Pathology)
  • Survival

Fields of Study

  • Medicine

Readers

  • Combustion Dynamics and Shock Wave Physics.
  • Immunology and Pathology
  • Neurotrauma and Rehabilitation Medicine.