Mean Arterial Pressure and Cerebral Blood Flow Regression for Prediction of Central Nervous System Oxygen Toxicity

Abstract

One toxic effect of hyperbaric oxygen (HBO) exposure is tonic-clonic seizures. To assess the association between seizure onset, mean arterial pressure (MAP) and cerebral blood flow (CBF), male Yorkshire swine were chronically instrumented to measure those parameters during exposure to 3, 4, 5 or 6 atmosphere absolute (ATA) on 100% oxygen. Seizure latency differed significantly as a function of pressure (P <0.05). The increase in MAP and CBF correlated with seizure latency and multiple regression analysis demonstrated that MAP and CBF jointly predict seizure latency. These results demonstrate that a measurable increase in MAP and CBF may be a useful predictive tool, which may improve the safety of diving operations and clinical treatments requiring HBO. seizure,

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2004
Accession Number
ADA445848

Entities

People

  • Andreas Fahlman
  • C. D. Forcino
  • John Braisted
  • Sheri B. Parker

Organizations

  • Naval Medical Research Center

Tags

DTIC Thesaurus Topics

  • Arteries
  • Biomedical Research
  • Blood
  • Blood Flow
  • Brain
  • Cardiovascular Physiological Phenomena
  • Central Nervous System
  • Decompression Sickness
  • Diving Operations
  • Epilepsy
  • Governments
  • Nervous System
  • Regression Analysis
  • Seizures
  • Statistical Analysis
  • Surgery

Readers

  • Cardiovascular Physiology
  • Marine Mammal Biology
  • Toxicology/Environmental Toxicology