Biological Effects of Activating Distinct ErbB Receptor Dimers in Polarized Growth Arrested Epithelia

Abstract

Malignant breast cancer appears to develop over time from mammary epithelial cells that have been transformed. These transformed cells form early lesions that are characterized by loss of epithelial architecture and uncontrolled proliferation. Currently, early lesions are defined using histological techniques and the molecular features that distinguish different histological types are not known. Although oncogenes implicated in breast cancer have been described, how they specifically interfere with tissue architecture giving rise to different histopathological patterns remain to be elucidated.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2005
Accession Number
ADA446324

Entities

People

  • Marissa E. Moore
  • Senthil K Muthuswamy

Organizations

  • Cold Spring Harbor Laboratory

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Breast Cancer
  • Cell Line
  • Cell Polarity
  • Cells
  • Culture Techniques
  • Department Of Defense
  • Epithelial Cells
  • Epithelium
  • Growth Factors
  • Intercellular Junctions
  • Mammary Glands
  • Neoplasms
  • Peptide Growth Factors
  • Three Dimensional
  • Tissues
  • Tyrosine

Fields of Study

  • Medicine

Readers

  • Molecular Biology and Genetics
  • Oncology and Biomarker-Based Cancer Detection.