Pim Protein Kinase-Levels Correlate With Prostate Tumor Growth and Chemo-Resistance - Potential Mechanism of PIM Action

Abstract

Pim is a protein kinase that has been implicated to play a role in prostate cancer. Kaplan-Meier analysis demonstrated that those patients with high Pim-1 expression are at a significantly greater risk for developing metastatic cancer. In transgenic animal models, the levels of Pim-1 protein kinase are elevated in prostate tumors caused by over expression of the c-myc ongoene, a gene over expressed in human prostate cancer. In this proposal we will examine whether Pim mimics Akt and TOR or modulates additional biochemical pathways, and use knockout mice to dissect how myc and Pim collaborate to induce transformation and growth or prostate cancers. Pim inhibitors alone or in combination with TOR inhibitors will make a powerful chemotherapeutic strategy.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2005
Accession Number
ADA446335

Entities

People

  • Andrew S Kraft

Organizations

  • Medical University of South Carolina

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Anti-Bacterial Agents
  • Biological Factors
  • Biomedical And Dental Materials
  • Blood
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Chemotherapy
  • Growth Factors
  • Inhibitors
  • Neoplasms
  • Peptides
  • Prostate Cancer
  • Proteins
  • Resistance
  • Sodium Compounds

Fields of Study

  • Biology

Readers

  • Battery Technology and Engineering
  • Molecular Biology and Genetics
  • Prostate Cancer Biology.