Molecular Mechanism of Nkx3.1 Deregulation and Its Function in Murine Pten Prostate Cancer Model

Abstract

Both PTEN and Nkx3.1 play important role in prostate cancer control. Preliminary results from Pten prostate model indicated that reduced Nkx3.1 expression is correlated with Cre-mediated Pten deletion. The goal of this study is to investigate how these two proteins interplay in prostate cancer development. We generated and characterize the primary cell lines from Pten prostate cancer model, which will facilitate us to study the molecular mechanism of Nkx3.1 deregulation by Pten loss. We demonstrate that restoration of Nkx3.I into Pten null prostate epithelium can lead to increases cell apoptosis, decreased cell proliferation and prevention of tumor initiation. The anti-tumor effect of Nkx3.1 is correlated with stabilization p53, inhibition Akt activation and AR function.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2005
Accession Number
ADA446368

Entities

People

  • Jing Jiao

Organizations

  • University of California, Los Angeles

Tags

DTIC Thesaurus Topics

  • Androgen Receptors
  • Apoptosis
  • Biological Sciences
  • Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Department Of Defense
  • Diseases And Disorders
  • Epithelium
  • Genetics
  • Neoplasms
  • Prostate Cancer
  • Proteins
  • Stem Cells
  • Tissues

Fields of Study

  • Biology

Readers

  • Astronomy and Astrophysics.
  • Molecular Biology and Genetics
  • Prostate Cancer Biology.