A New Marker for Tamoxifen Resistance in ER-Dependent Breast Cancer

Abstract

While the significance of the protein kinase AKT expression lactivity in human breast cancer has become increasingly evident, consistent alterations of a specific isoform have not been well documented, A specific isoform of AKT may be preferentially activated or activated proteins may have different substrate preferences, providing a therapeutic opportunity to target a particular isoform. Previously, we have demonstrated a cross-talk between the growth factor and estrogen transduction pathways, converging in the ErbB2/PI 3-K/AKT1 signaling.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2005
Accession Number
ADA446369

Entities

People

  • Adriana Stoica

Organizations

  • Georgetown University

Tags

DTIC Thesaurus Topics

  • Alkenes
  • Biomedical Research
  • Biotechnology
  • Breast Cancer
  • Carcinoma
  • Cells
  • Cellular Structures
  • Cytoplasm
  • Diseases And Disorders
  • Growth Factors
  • Hormones
  • Immunohistochemistry
  • Kinases
  • Lymph Nodes
  • Neoplasms
  • Phosphorylation
  • Resistance

Fields of Study

  • Biology

Readers

  • Breast cancer cell signaling and growth regulation.
  • Systems Analysis and Design