Castration-Induced Neuroendocrine Mediated Progression of Prostate Cancer

Abstract

This progress report highlights our past 12 months of work on understanding neuroendocrine differentiation in prostate cancer (CaP). We have made headway into understanding the paracrine relationship between neuropeptide expressing CaP cells and androgen-insensitive CaP cells. Specifically the ability for neuropeptide expressing CaP cells to support the proliferation and migration of the androgen sensitive CaP cells in an environment without androgens (castrate). The more detailed, in vivo experiments will provide a model to look at the relationship in a temporal fashion at the time of castration.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2005
Accession Number
ADA446371

Entities

People

  • Christopher P Evans

Organizations

  • University of California

Tags

DTIC Thesaurus Topics

  • Androgens
  • Castration
  • Cell Line
  • Cell Movement
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Culture Media
  • Department Of Defense
  • Environment
  • Hormones
  • Migration
  • Neoplasms
  • Peptides
  • Prostate
  • Prostate Cancer

Readers

  • Oncology (Cancer Research).
  • Prostate Cancer Biology.
  • Theoretical Analysis.