Regulation of AR and (Beta)-Catenin Signaling by Pin 1 in Prostate Cancer
Abstract
This mid-term report is a summary of the work accomplished during the past research year. The majority of this work was included in the attached Manuscript. Additional data were also included. Together our data support a positive role of Pin1 in PCa progression. We demonstrated that Pin1 can enhance beta-catenin nuclear localization, TCF/beta-catenin dependent promoter activity, and c-Myc and Cyclin D1 expression, while disrupt AR-mediated suppression of TCF/beta-catenin signaling. We also determined that Pin1 can reduce AR transcriptional activity and PSA expression, although the importance and the molecular basis for this Pin1 action are still not clear.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2005
- Accession Number
- ADA446378
Entities
People
- Shaoyong Chen
Organizations
- Beth Israel Deaconess Medical Center