Cyclin Dependent Kinase Inhibitors as Targets in Ovarian Cancer

Abstract

The objective of this proposal is to develop gene therapy strategies that inhibit ovarian cancer cell growth and selectively improve sensitivity of ovarian cancer cells to chemotherapy and radiation. The proposal focuses on invitro and in vivo `%proof- of-concept" studies of target discovery. Four highly interactive projects make up this proposal. We have identified key genes that may be effective targets in ovarian cancer therapy. The first three projects seek to identify alterations in these genes which, either alone or in combination with chemotherapy or radiation, will efficiently kill ovarian cancer cells. Project 4 will identify promoters that allow for high expression of our key gene(s) in ovarian cancer cells but minimal expression in normal tissues.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2005
Accession Number
ADA446399

Entities

People

  • Stephen D. Williams

Organizations

  • Indiana University

Tags

DTIC Thesaurus Topics

  • Brain
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Health Services
  • Medical Personnel
  • Proteins

Readers

  • Molecular Biology and Genetics
  • Oncology

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech