Aberrant AR Signaling as a Function of Declining Androgen

Abstract

This is an Exploration - Hypothesis Development Award (EHD) in which we modeled in a mouse model system the natural androgen decline in the aging male (ADAM) as it occurs after the age of 40 years in humans. ADAM coincides with a dramatic increase in the prostate cancer incidence in all population groups. To date we have collected all biological specimens and are in the process of detailed analyses. We have also explored androgen receptor (AR) signaling in pilot studies to allow a better understanding of this axis in ADAM. Five publications are in press.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2005
Accession Number
ADA446410

Entities

People

  • Gerhard A. Coetzee
  • Jacek Pinski

Organizations

  • University of Southern California

Tags

DTIC Thesaurus Topics

  • Androgen Receptors
  • Biomedical And Dental Materials
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Epithelial Cells
  • Gene Expression
  • Medical Personnel
  • Molecular Biology
  • Polymer Chemistry
  • Polymeric Films
  • Prostate Cancer
  • Proteins

Readers

  • Mathematics or Statistics
  • Prostate Cancer Biology.
  • Team-Based Human-Centered Cognitive Task Decision Making and Information Performance.