MIC-1, A Potential Inhibitor of Breast Tumor Progression

Abstract

MIC-1/GDF-l5 is a newly identified member of the TGF-beta superfamily of growth and differentiation factors. MIC-1/GDF-15 is highly expressed in both animal models and patients with breast cancer. MIC-1/GDF-15 is induced by chemotherapy. In order to understand the role of MIC-1/GDF-15 in breast cancer development the grant sought to breed wild-type and GDF-15 null mice into two mice lines with a genetic predisposition for breast cancer formation the (TgN(C3-1-TAg) and APC-min mouse lines. The project has had some setbacks but has begun the breeding to obtain the animals of interest to examine the effect of GDF-15 loss on tumor initiation, progression and metastasis.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2005
Accession Number
ADA446419

Entities

People

  • Leonidas G. Koniaris

Organizations

  • University of Miami

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Breast Cancer
  • Breeding
  • Cancer
  • Carcinogens
  • Cell Line
  • Cells
  • Chemotherapy
  • Colon Cancer
  • Drug Therapy
  • Growth Factors
  • Inhibitors
  • Metastasis
  • Neoplasms
  • Neurons
  • Peptide Growth Factors
  • Prostate Cancer

Readers

  • Molecular Biology and Genetics

Technology Areas

  • Biotechnology
  • Fully Networked C3
  • Fully Networked C3 - Command and Control