Fibroblast Growth Factor Receptor-4 and Prostate Cancer Progression

Abstract

We have found that the FGFR-4 Arg388 allele is strongly associated with the occurrence of prostate cancer and with metastasis and PSA recurrence in men undergoing radical prostatectomy. We will test the role of FGFR-4 in prostate cancer metastasis using autochthonous and orthotopic mouse models of cancer. We will also identify changes in gene expression due to the presence of the FGFR-4 Arg388 allele that lead to the metastatic phenotype. To this end we have established and carried out the initial characterization of trangenic mice with prostatic specific expression of FGFR-4 Arg388 and Gly388; constructed a FGFR-4 siRNA lentivirus and a PC3 siRNA cell line and identified Ehm2 as an FGFR-4 Arg388 regulated gene and characterized its role in prostate cancer. These key reagents will allow us to evaluate the effects of FGFR-4 on prostate cancer progression in vivo. Further studies of FGFR-4 Arg388 regulated gene expression in prostate cancer tissues are underway.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2005
Accession Number
ADA446482

Entities

People

  • Michael M. Ittmann

Organizations

  • Baylor College of Medicine

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Cancer
  • Carcinoma
  • Cell Line
  • Cells
  • Diseases And Disorders
  • Epithelial Cells
  • Fibroblasts
  • Gene Expression
  • Genes
  • Genetics
  • Growth Factors
  • Metastasis
  • Neoplasms
  • Prostate Cancer
  • Proteins
  • Tissues

Fields of Study

  • Biology

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