Mechanism of Tissue Remodeling in Sepsis-Induced Acute Lung Injury

Abstract

Acute lung injury (ALI) is a major cause of morbidity and mortality in the U.S., and sepsis is a common cause. We have found that chronic ethanol abuse renders the host susceptible to ALI. This project explores the mechanisms by which ethanol affects the lung focusing on lung fibroblasts. Specifically, it uses in vitro and in vivo models to evaluate the mechanisms of lung tissue remodeling in the setting of chronic ethanol exposure and sepsis.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2005
Accession Number
ADA446567

Entities

People

  • David M. Guidot
  • Jesse Roman

Tags

DTIC Thesaurus Topics

  • Acute Respiratory Distress Syndrome
  • Biomedical Research
  • Cells
  • Connective Tissue
  • Cytokines
  • Digestive System Processes
  • Education
  • Endotoxins
  • Epithelial Cells
  • Fibroblasts
  • Lung Diseases
  • Macrophages
  • Morbidity
  • Proteins
  • Tissues
  • Transcription Factors
  • Wounds And Injuries

Fields of Study

  • Medicine

Readers

  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.
  • Molecular Biology and Genetics
  • Trauma or Military Medicine