The Role of RAs in Myc-Induced Mammary Tumorigenesis

Abstract

We have previously demonstrated that induced MYC oncogene expression in the murine mammary epithelium results in the formation of mammary tumors. MYC-induced tumors known to have Kras2 mutations all fail to regress after MYC deinduction while most tumors without the mutations do regress. We have attempted to build a second transgenic mouse model to regulate Kras2 expression independently of MYC in the mammary gland. After testing and characterizing the transgenic mice from this system, we have concluded that this system cannot be successfully used to regulate Kras2 in the mammary gland. As an alternative method, we are currently attempting to retrovirally infect MYC-induced tumors cells with virus expressing active Kras2.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2005
Accession Number
ADA446568

Entities

People

  • Joanne Jang

Organizations

  • University of Pennsylvania

Tags

DTIC Thesaurus Topics

  • Alkynes
  • Anatomy
  • Biological Sciences
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cells
  • Department Of Defense
  • Electronic Mail
  • Genetic Structures
  • Genetically Modified Organisms
  • Glands
  • Mammary Glands
  • Mutations
  • Neoplasms
  • Tissues

Fields of Study

  • Medicine

Readers

  • Molecular Biology and Genetics