Regulation of Intracellular pH in Lungs and Other Tissues During Hypercapnia
Abstract
Using a 14C-labeled DMO, 36Cl, and 3H method, we have determined the in vivo buffering capacity of lung, kidney, heart, skeletal muscle, and extracellular fluid (ECF) of guinea pigs during hvpercapnia. After 1 day's exposure to 15% CO2, both the relative CO2 buffer values and the "%pH regulation" were lung > kidney > heart > ECF > skeletal muscle. For lung tissue the intracellular pH was significantly decreased only during acute (8 h) hypercapnia and had completely returned to control values after 7 days with arterial Pco-2 = 122 Torr. Kidney and cardiac muscle also showed ca. 100% regulation of pH at 7 days, whereas skeletal muscle and ECF showed only 80 and 70% pH regulation, respectively. The results are discussed with respect to the important (and pH-dependent) metabolic functions of the lung and kidney.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 10, 1978
- Accession Number
- ADA446584
Entities
People
- Karl E. Schaefer
- Stephen C. Wood
Organizations
- Naval Submarine Medical Research Laboratory