Develpment of a Microfluidic Device for the Study of Breast Cancer Cell Migration

Abstract

This project focuses on the development of microfluidic chambers for the study of breast cancer cell chemotaxis. We are continuing our work on characterizing breast cancer cell chemotaxis in epidermal growth factor (EGF) gradients. We developed a parallel gradient microfluidic chemotaxis chamber, allowing different gradients to be generated side by side. Using this chamber, we compared the effects of different EGF gradients on breast cancer cell chemotaxis, and observed subtle different in the migratory response. We also characterized the effect of an EGFR antagonist on chemotaxis. As we move forward in this project, we will continue to investigate breast cancer cell chemotaxis in different gradient conditions and different chemoattractants.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2005
Accession Number
ADA446737

Entities

People

  • Noo L. Jeon
  • Wajeeh M. Saadi

Organizations

  • University of California, Irvine

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Albumins
  • Anti-Bacterial Agents
  • Biomedical Engineering
  • Biomedical Research
  • Blood
  • Blood Vessels
  • Breast Cancer
  • Cell Line
  • Cell Movement
  • Cells
  • Department Of Defense
  • Growth Factors
  • Migration
  • Neoplasms
  • Orientation (Direction)
  • Proteins
  • Soft Lithography

Readers

  • Atmospheric Science / Meteorology, specifically Wind Wave Turbulence.
  • Immunology and Pathology
  • Molecular Biology and Genetics