The Effect of Hypotensive Resuscitation and Fluid Type on Mortality, Bleeding, Coagulation, & Dysfunctional Inflammation in a Swine Grade V Liver Injury Model

Abstract

Exsanguination is the leading cause of death on the battlefield. Lifesaving interventions include arresting hemorrhage and initiating resuscitation. The ideal resuscitation of combat casualties has not been determined. Delaying resuscitation has been shown to be beneficial in some settings and anesthetics utilized can have a profound effect on the resuscitation. The goal of this proposal is to determine the ideal resuscitation regimen of swine undergoing a Grade V liver injury followed by 30 minutes of uncontrolled hemorrhagic shock. Fluids studied include lactated Ringer's (LR), normal saline (NS) and various concentrations of hypertonic saline. Fluids were evaluated based on their effects on mortality, metabolic changes, blood pressure, tissue oxygenation and inflammatory changes measured in the lung. The effect of total intravenous anesthesia (TIVA) on the model was also studied.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2006
Accession Number
ADA446801

Entities

People

  • Martin Schreiber

Organizations

  • Oregon Health & Science University

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Airway Management
  • Anesthesia
  • Anesthetics
  • Arteries
  • Blood
  • Cardiovascular Physiological Phenomena
  • Chemistry
  • Gene Expression
  • Granulocytes
  • Hemorrhage
  • Hemorrhagic Shock
  • Inflammation
  • Oxygenation
  • Resuscitation
  • Time Intervals
  • Veins

Fields of Study

  • Medicine

Readers

  • Trauma Surgery or Emergency Medicine.