Molecular Characterization of Prostate Cancer Cell Oncolysis by Herpes Simplex Virus ICP0 Mutants

Abstract

This report outlines the progress made on our Exploration: Hypothesis Development Award within the past 12 months. Briefly, the goals of the proposal were to characterize the oncolytic capacity of Herpes simplex virus type 1 ICPO mutants in prostate cancer cells given the relationship between ICPO and two tumor suppressors, RNase L and PML, implicated in prostate cancer progression. Here, we report that ICPO prevents an RNase L-independent rRNA degradation event in infected cells (appended manuscript). We also provide preliminary evidence that suggests that the ability of ICP0-null HSV-1 mutants to selectively kill prostate cancer cells correlates with a reduction in PML levels. Furthermore, we briefly discuss experiments to be completed within the remaining six months of this award.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2005
Accession Number
ADA446961

Entities

People

  • Karen Mossman

Organizations

  • McMaster University

Tags

DTIC Thesaurus Topics

  • Biomedical And Dental Materials
  • Biomedical Research
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Defense Mechanisms
  • Degradation
  • Interferon
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Proteins
  • Rna Stability
  • Transcription Factors
  • Virology
  • Viruses

Readers

  • Breast cancer cell signaling and growth regulation.
  • Medical Imaging.
  • Virology (or Medical Virology).