Targeting the MTA 1s-LM04 Pathway in Hormone Resistance

Abstract

The overall goal of this research is to determine the role of LMO4 in breast cancer progression. New insight into these concepts will likely provide new targets and strategies for therapeutic intervention. We have identified estrogen receptor alpha (ER) and its corepressors MTA1 and MTA1s as novel binding partners of LMO4 and have shown that LMO4 is essential to maintain ER transcriptional repression in breast cancer cells. This work was reported in a recent Cancer Research article. Since LMO4 is up regulated in human breast cancers, repression of alpha (ER) transactivation functions by LMO4 might contribute to the process of breast cancer progression by allowing the development of ERa-negative phenotypes and hormone resistance, leading to increased aggressiveness of breast cancer cells.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2005
Accession Number
ADA446963

Entities

People

  • Christopher J. Barnes

Organizations

  • The University of Texas MD Anderson Cancer Center

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cell Movement
  • Cells
  • Chemistry
  • Confocal Microscopy
  • Enzyme Inhibitors
  • Epithelial Cells
  • Gene Expression
  • Genetic Structures
  • Genetics
  • Hormones
  • Mammary Glands
  • Neoplasms

Readers

  • Breast cancer cell signaling and growth regulation.