Interfering With DNA Damage Signals: Radiosensitizing Prostate Cancer Using Small Peptides
Abstract
The focus of this project is to evaluate a newly developed small peptide on its ability to block DNA damage signaling pathways and to sensitize prostate tumor cells to radiotherapy. One of the critical DNA damage pathways which determine radiosensitivity is medicated by ATM and its phosphorylation of downstream targets, including Structural Maintenance of Chromosomal protein one (SMC1). Previously we have demonstrated that small fusion peptides containing SMC1 phosphorylation sequences can inhibit ATM activity. During the last performance period, we have characterized the inhibitory effect of the THM-SMC1 peptide on cellular response to radiation and found the peptide can abolish radiation induced S-phase checkpoint and decrease prostate tumor cell clonogenic survival. Current experiments are focusing on the mechanistic insight on how these inhibitory peptides work.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 2005
- Accession Number
- ADA446988
Entities
People
- Bo Xu
Organizations
- Louisiana State University