Biomimetic Composite Scaffold for Breast Reconstruction Following Tumor Resection
Abstract
The overall, long-term objective of this innovative proposal was to develop a clinically translatable strategy to restore the breast mound following mastectomy or lumpectomy such that patient quality of life and outcomes are markedly improved. We hypothesized that a novel composite material consisting of silk fibroin and chitosan will act as a biomimetic scaffold amenable to in vivo adipogenesis. The specific aims (SAs) of this I-year proposal were to (I) develop a rational portfolio of composite materials by combining silk fibroin and chitosan under various fabrication conditions, (2) characterize the materials using defined metrics and select a set of candidate materials based on mechanical and ultrastructural properties, (3) determine in vitro cytocompatibility and preadipocyte seeding parameters of the candidate materials, and (4) determine in vivo applicability of the preadipocyte-seeded candidate materials using a short-term rat subcutaneous pocket assay. All aims have been accomplished within the I-year time frame. Academic outcomes include the current preparation of several manuscripts, several presentations at national/international conferences, and the training of several research interns.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2005
- Accession Number
- ADA447054
Entities
People
- Charles W. Patrick Jr.
Organizations
- The University of Texas MD Anderson Cancer Center