The Effect of Glycolytic Modulation on Prostrate Cancer
Abstract
In this proposal, we focus on, and have preliminary data to support, a novel approach targeting metabolism (by inhibition of glycolysis) to compliment ongoing clinical efforts to abrogate growth factor and apoptotic pathways in prostate cancer. The proposed clinical and laboratory studies are relevant to prostate cancer, given preliminary data demonstrating the importance of modulation of the glycolytic pathway in prostate cancer cell lines independent of activation of Akt and overexpression of Bcl- 2, both common mechanisms of resistance in prostate cancer. We have put together an effective translational team capable of both laboratory efforts and development of clinical trials to develop this program and test this novel paradigm. In this regard, the proposal will involve both preclinical and clinical development. The potential of this proposal includes the reassessment of a metabolic pathway to begin a totally new area of cancer therapeutics in which we abrogate the critical nutrient pathway required for the development of oncogenic mechanisms of resistance.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 2005
- Accession Number
- ADA447226
Entities
People
- Robert S. Dipaola
Organizations
- University of Medicine and Dentistry of New Jersey