V.I.T.A.L. (Vanguard Investigations of Therapeutic Approaches to Lung Cancer)
Abstract
The VITAL Research Program has three primary objectives that are being addressed through a series of innovative and integrated research studies: (1) to develop biologically-based treatments for the prevention of disease recurrence and of the development of second primary tumors in patients at risk for these events, (2) to improve understanding of the molecular events in pre-malignant tissue that underlie the progression to malignancy, and (3) to combine data based on treatment outcomes with molecular and imaging data to create a risk model for disease recurrence and development of second primary tumors in patients at risk for these events. Achieving these objectives will have the immediate direct effect of reducing the mortality rate for patients with a prior smoking-related cancer who are at high risk of relapse or development of a smoking-related second primary tumor. Achieving these objectives will contribute to the long-term goal of identifying a safe, efficacious agent or combination of agents that can be used in high-risk populations for prevention of lung cancer. Project 1 addresses Biologic Approaches for Adjuvant Treatment of Aerodigestive Tract Cancer. Project 2 identifies Biomarkers of Response to Chemoprevention Agents in Lung Epithelium. Project 3 examines Premalignant Bronchial Epithelia -- Molecular and Cellular Characterization of Lung Tumorigenesis. Project 4 focuses on Modulation of Death Receptor-Mediated Apoptosis for Chemoprevention. Project 5 examines Molecular Strategies Targeting the AKT Signaling Pathway for Lung Cancer Chemoprevention and Therapy. Developmental Research Project 1 focuses on an Enhanced Oral/Head and Neck Examination Protocol, and Developmental Research Project 2 looks at Biomarkers for Aggressive Lung Carcinomas in African American Men. The paper also reviews Core B, Biostatistics and Data Management, and Core C, Pathology and Specimen Procurement.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2005
- Accession Number
- ADA447623
Entities
People
- Waunki Hong
Organizations
- The University of Texas MD Anderson Cancer Center