Prostasin's Role in Prostate Cancer
Abstract
We have shown, in an alternative model system (of the mouse bladder) via collaborative research, that prostasin serine protease is capable of attenuating LPS-induced inflammatory gene expression response, specifically the mRNA expression of inducible nitric oxide synthase (iNOS), by potentially intercepting cytokine signaling at the cytokine receptor level. A new candidate protein, gp13O, the signal transducer of the interleukin-6 receptor complex, has been proposed to be the 12O-13O-kDa tyrosinephosphorylated protein regulated by prostasin in the DU-145 and PC-3 cells, as presented in the original proposal. Efforts are underway to demonstrate the applicability of this new molecular mechanism in the prostate cancer cell line PC-3, which had been shown by others to respond to inflammatory challenges such as LPS and cytokines through upregulation of the iNOS gene expression, while over-expressing the gp13O signal transducer. This new working hypothesis directly related to the original proposal will potentially lead to better understanding of the role of inflammation in prostate cancer biology.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 2005
- Accession Number
- ADA447815
Entities
People
- Karl Chai
- Limei Chen
Organizations
- University of Central Florida