Molecular Dissection of the Human Antibody Response to the Structural Repeat Epitope of Plasmodium falciparum sporozoite from a Protected Donor

Abstract

The circumsporozoite surface protein is the primary target of human antibodies against Plasmodium falciparum sporozoites, these antibodies are predominantly directed to the major repetitive epitope (Asn-Pro-Asn-Ala)n, (NPNA)n. In individuals immunized by the bites of irradiated Anopheles mosquitoes carrying P. falciparum sporozoites in their salivary glands, the antirepeat response dominates and is thought by many to play a role in protective immunity.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jul 29, 2004
Accession Number
ADA447960

Entities

People

  • Angray S. Kang
  • Jonathan A. Chappel
  • Stephen L. Hoffman
  • William O. Rogers

Organizations

  • Scripps Research

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Antibodies
  • Biomedical Research
  • Blood
  • Cells
  • Chemistry
  • Hepatitis
  • Immune Serums
  • Immunity
  • Immunization
  • Immunoglobulins
  • Malaria
  • Molecular Biology
  • Molecules
  • Proteins
  • Public Health
  • Sporozoites
  • Vaccines

Fields of Study

  • Biology
  • Medicine

Readers

  • Immunology
  • Neuroscience
  • Parasitology and Pharmacology of Malaria.