Restoration of Wild-Type Activity to Mutant p53 in Prostate Cancer: A Novel Therapeutic Approach
Abstract
A summary is presented of research performed during the first year of a project to determine feasibility of approaches to restore wild-type transcriptional activity on mutant p53 proteins found in human prostate tumors. p53 mutant proteins that are specifically relevant to prostate cancer are being examined to determine whether they are suitable targets for such an approach. Three specific aims are being pursued. The first is characterizing the interaction of p53 with two distinct classes of its response elements. The second aim is determining the role of mutant p53 proteins in prostate cancer cell proliferation. The final aim is to explore approaches to restore wild-type function to mutant p53 proteins found in prostate cancer. The long term goals of this research is to identify small molecular weight compounds which have the novel activity of restoring wild-type function to prostate cancer derived mutant p53 proteins. As such, this represents a preclinical development of highly targeted therapy with the hope of establishing highly effective and tumor-specific treatments of human prostate cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2006
- Accession Number
- ADA448036
Entities
People
- James Manfredi
Organizations
- Icahn School of Medicine at Mount Sinai