Immunogenicity of Combination DNA Vaccines for Rift Valley Fever Virus, Tick-Borne Encephalitis Virus, Hantaan Virus, and Crimean Congo Hemorrhagic Fever Virus

Abstract

DNA vaccines for Rift Valley fever virus (RVFV), Crimean Congo hemorrhagic fever virus (CCHFV), tick-borne encephalitis virus (TBEV), and Hantaan virus (HTNV), were tested in mice alone or in various combinations. The bunyavirus vaccines (RVFV, CCHFV, and HTNV) expressed Gn and Gc genes, and the flavivirus vaccine (TBEV) expressed the preM and E genes. All vaccines were delivered by gene gun. The TBEV DNA vaccine and the RVFV DNA vaccine elicited similar levels of antibodies and protected mice from challenge when delivered alone or in combination with other DNAs. Although in general, the HTNV and CCHFV DNA vaccines were not very immunogenic in mice, there were no major differences in performance when given alone or in combination with the other vaccines.

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Document Details

Document Type
Technical Report
Publication Date
Aug 22, 2005
Accession Number
ADA448467

Entities

People

  • Amy Shurtleff
  • Anita McElroy
  • Connie S Schmaljohn
  • Jay W. Hooper
  • Kristin Spik
  • Mary C. Guttieri

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Antibodies
  • Antigens
  • Cells
  • Chemistry
  • Culture Techniques
  • Diseases And Disorders
  • Encephalitis
  • Equine Encephalitis
  • Immunogenicity
  • Infectious Diseases
  • Proteins
  • Rift Valley Fever
  • Rift Valleys
  • Vaccines
  • Virus Diseases
  • Viruses

Fields of Study

  • Biology

Readers

  • Virology (or Medical Virology).

Technology Areas

  • Biotechnology