Promoting Breast Cancer Cell Invasion by Matrix Metalloproteinase 26 in a Novel Three-Dimensional PVA Sponge Culture System
Abstract
Proteolytic degradation of the basement membrane (BM) and extracellular matrix (ECM) is a critical prerequisite for breast carcinoma cell invasion, and matrix metalloproteinases (MMPs) are thought to play important roles during this process. MMP-26 (endometase/matrilysin-2), a novel member of this enzyme family recently cloned and characterized (1), is primarily expressed in cancers of epithelial origin, such as those of the breast, endometrium, and prostate. We have shown that MMP-26 promotes prostate cancer cell invasion by activating another powerful MMP, pro-gelatinase B (MMP-9) (2). We have also demonstrated that the MMP-26 protein is highly expressed in human breast ductal carcinoma in situ (DCIS) and during the early stages of human breast ductal invasive carcinoma (3), while little to no MMP-26 protein expression is detected in normal and hyperplastic tissues.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2005
- Accession Number
- ADA448489
Entities
People
- Yunge Zhao
Organizations
- Florida State University