Genes Involved in Oxidation and Prostate Cancer Progression
Abstract
We are evaluating polymorphisms in genes involved in the genesis of oxidative species, the detoxification of oxidative species, or the repair of oxidative DNA damage influence the risk of prostate cancer progression in men with clinically organ confined prostate cancer. We recently received a no-cost extension through 01/15/2007, and thus this progress report is an annual progress report rather than final. During the past funding year we finalized the definition, selection, and matching of 524 cases (progressors) and 524 controls (non-progressors) with input from pathologists and biostatisticians. We characterized these individuals with respect to baseline demographic and clinical data to confirm that they are otherwise comparable. The source of DNA for these men, unaffected paraffin-embedded lymph nodes removed routinely at prostatectomy, has been located and pulled thus far for 13% of the participants; pulling the blocks is ongoing. Candidate genes in these pathways have been selected and key single nucleotide polymorphisms in these genes are being selected based on the newly available HapMap.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2006
- Accession Number
- ADA448494
Entities
People
- Elizabeth A Platz
Organizations
- Johns Hopkins University