Prognostic Value of Allelic Imbalance in Prostate Biopsy
Abstract
The novel concept that is being tested in this project is that allelic imbalance (AI) in tissue obtained at prostate biopsy can serve as a sensitive and independent marker for staging and predicting disease recurrence in prostate cancer. The two aims of the project are (1) to determine whether the number of sites of AI in biopsy predicts pathological staging following prostatectomy, and (2) to determine the independence, positive and negative predictive values, and sensitivity of AI in biopsy tissues as a prognostic marker for prostate cancer. The number of sites of AI has been measured in DNA from 110 prostatectomy tissues, 83 tumor adjacent, histologically normal prostate tissues, 43 biopsy specimens with a positive diagnosis of prostate cancer, and 22 specimens of normal prostate tissue from men without disease. The results demonstrate that AI is increased (1) in tumor and tumor-adjacent prostate tissues relative to normal prostate tissues, (2) as a function of Gleason Sum, and (3) in recurrent prostate tumors. Allelic imbalance in prostate cancer tissues may provide a novel diagnostic and prognostic marker.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2005
- Accession Number
- ADA448497
Entities
People
- Jeffrey K. Griffith
Organizations
- University of New Mexico