Cancer Localization in the Prostate with F-18 Fluorocholine Positron Emission Tomography
Abstract
An imaging technique to identify the regions of cancer in the prostate gland could significantly enhance the diagnosis, treatment, and surveillance of this disease. This project evaluates fluorine-18 fluorocholine (F-18 FCH) positron emission tomography (PET) as a method for localizing cancer in the prostate gland. The research study plans to accrue 25 subjects who are undergoing radical prostatectomy surgery for prostate cancer. The subjects will undergo pre-operative PET scanning to acquire images of F-18 FCH uptake in anatomical sextants of the prostate. These results will be compared to the results of prostate biopsy and histopathologic analysis of the prostate specimen following surgery to determine the accuracy of F-18 FCH PET for detecting cancer in prostate sextants. The first major task of the project involved development of the human subjects research protocol and its approval by the institutional review board (IRB) at two medical institutions as well as the U.S. Army Human Subjects Research Review Board. Following completion of these tasks, subject recruitment was begun on July 18, 2005. As of December 20, 2005, 10 subjects have participated in the research. Analysis of the preliminary data reveals that benign and malignant prostate sextants demonstrate statistically significant differences in F-18 FCH uptake as measured by PET. These preliminary findings concur with data obtained from a previous pilot study and support potential diagnostic and therapeutic applications for this technique. Because the average tumor volume from the first 5 subjects was less than expected, a protocol change was submitted to the IRB in December 2005 to allow the inclusion of patients who may have higher tumor volumes. Project tasks that were assigned to the first project year have been completed in accordance to the Statement of Work (SOW). Completion of the remaining tasks is expected within the time frame of the SOW.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2006
- Accession Number
- ADA448533
Entities
People
- Sandi Kwee
Organizations
- The Queen's Medical Center