Generation Sampling and Analysis for Low-Level GB (SARIN) Vapor for Inhalation Toxicology Studies

Abstract

This study tested and optimized various methodologies to generate, sample, and characterize sarin (GB) test atmospheres in an inhalation chamber, particularly at low-vapor levels. A syringe drive/spray atomization system produced GB vapor at lethal concentrations of 1-44 mg/m3. A saturator cell was used to generate GB vapor at sub-lethal concentrations from 1 mg/m down to very low GB levels approaching the TLV-TWA of 0.0001 mg/m3. Both generation techniques demonstrated the ability to produce stable vapor concentrations over extended exposure periods. This capability was important to determine sub-lethal nerve agent effects for inhalation toxicology studies. In addition, the techniques employed for producing and maintaining low-level GB vapor would lay the foundation for testing other chemical warfare agents, such as GF or VX.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2006
Accession Number
ADA448866

Entities

People

  • Charles L. Crouse
  • Kathy L. Matson
  • Sandra A. Thomson
  • William T. Muse Jr.

Organizations

  • Edgewood Chemical Biological Center

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Atmospheres
  • Atomization
  • Chemical Warfare
  • Chemical Warfare Agents
  • Chemical Weapons
  • Chemistry
  • Demographic Cohorts
  • Detectors
  • Engineering
  • Generators
  • Nerve Agents
  • Physical Properties
  • Rodents
  • Sampling
  • Standards
  • Toxicology
  • Vapor Pressure

Fields of Study

  • Environmental science

Readers

  • Analytical Chemistry
  • Combustion science or combustion engineering.
  • Marine Mammal Biology