Synthesis of Diketopiperizine Peptide Derivatives by Cross-Metathesis
Abstract
The olefin CM reactivity and selectivity of amino acid derivatives with a cyclic scaffold to generate diketopiperizine peptide derivatives were investigated. Product yields were dependent on the amino acid R groups, and whether the amino acid possessed an allyl or homoallyl moiety at the caroxylate side. The stereoselectivity of the dipeptide derivatives was found to be predominantly trans.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2006
- Accession Number
- ADA448991
Entities
People
- Daniel Cooper
- Eric Enholm
- Ion Ghiviriga
- Tammy K. Low
Organizations
- University of Florida