Interleukin-12 Induces a Th1-like Response to Burkholderia mallei and Limited Protection in BALB/c Mice

Abstract

We evaluated the effect of interleukin (IL)-12 on the immune response to Burkholderia mallei in BALB/c mice. Mice were vaccinated with non-viable B. mallei cells with or without IL-12. There was a seven- to nine-fold increase in IgG2a levels, and a significant increase in the proliferative response and interferon (IFN)-gamma production by splenocytes from mice that received B. mallei and IL-12. We saw an increase in survivors in the groups of mice that received B. mallei and IL-12 when challenged, compared to mice that received only B. mallei or IL-12. The results suggest that IL-12 can enhance the Th1-like immune response to B. mallei and mediate limited protection from a lethal challenge.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Sep 02, 2005
Accession Number
ADA449193

Entities

People

  • David M. Waag
  • Jennifer L. Meyers
  • Kei Amemiya
  • Sarah L. Norris
  • Sylvia R. Treviño
  • Tran C. Chanh

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Adaptive Immunity
  • Biological Factors
  • Biological Sciences
  • Cells
  • Chemistry
  • Cytokines
  • Immune System
  • Immunity
  • Infection
  • Infectious Diseases
  • Interferon
  • Lymphatic System
  • Lymphocytes
  • Macrophages
  • Military Research
  • Proteins
  • Vaccines

Fields of Study

  • Medicine

Readers

  • Immunology
  • Toxicology/Environmental Toxicology

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech