Mechanisms and Chemoprevention of Ovarian Carcinogenesis
Abstract
Due to its asymptomatic development and frequent diagnosis at advanced stages, ovarian cancer is the most deadly among the gynecological cancers. A better understanding of the early molecular events leading to the disease is of utmost importance for the development of strategies for its efficient early diagnosis and prevention, which could improve patient survival and quality of life. We have shown that DMBA-induced mutagenesis in the rat ovary, combined with gonadotropin hormone-mediated enhanced mitogenesis of the ovarian surface epithelium gives rise to lesions ranging from preneoplastic to early neoplastic and advanced ovarian tumors, which resemble the human disease. The goal of the study is to use this animal model to study the molecular mechanisms behind ovarian oncogenesis and to conduct a preclinical trial for its chemoprevention. The aims of the study are: 1) Determine the molecular genetic mechanisms behind ovarian oncogenesis in the DMBA/gonadotropin-animal model; 2) Determine the efficacy of the COX-1 inhibitor SC-560 to prevent the appearance and/or progression of DMBA-induced ovarian lesions; and 3) Study the in vivo mechanisms of the putative chemopreventive effect of COX-2 inhibition. Genomic and mutation analyses, as well as other molecular biology assays will be employed to accomplish the objectives of the study.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 2006
- Accession Number
- ADA449486
Entities
People
- Christos Patriotis
Organizations
- Fox Chase Cancer Center