A Genetic Approach to Define the Importance of Rheb in Tuberous Sclerosis

Abstract

We have accomplished the generation of mice with an altered Rheb1 gene expression. In addition, we have also successfully generated an antibody which is highly specific for mouse Rheb2. Investigation into the function of Rheb GTPase and its significance in Tuberous Sclerosis is being studied.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2006
Accession Number
ADA449509

Entities

People

  • Fuyuhiko Tamanoi

Organizations

  • University of California, Los Angeles

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Animals
  • Antibodies
  • Biomedical Research
  • Biotechnology
  • Cassettes
  • Cell Line
  • Cells
  • Demographic Cohorts
  • Detection
  • Dilution
  • Gene Expression
  • Genes
  • Genetic Phenomena
  • Genetics
  • Proteins
  • Sclerosis

Readers

  • Aquatic Ecology
  • Molecular Biology and Genetics

Technology Areas

  • Biotechnology