An Essential Function of the N-Terminus of Ira/Neurofibromin
Abstract
The authors proposed to study a potentially new function of the yeast homolog of neurofibromin, Ira1. It is suggested from the literature that a complete deletion of Ira1 is lethal to yeast, while previous partial deletions of the same gene is viable. These seemingly conflicting results point to a possible essential function of the N-terminus of Ira1. However, the authors found that in their hands, a complete deletion of Ira1 is viable. Tetrad analysis was also carried out in the strains provided by the Saccharomyces genome deletion consortium and they got the same result. Therefore, the N-terminus of Ira1 does not possess any essential function in the yeast strains they have tested.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2006
- Accession Number
- ADA449525
Entities
People
- Vivianne Ding
Organizations
- University of California, San Francisco