DNA Microarray Analysis of Human Monocytes Early Response Genes upon Infection with Rickettsia rickettsii

Abstract

Rickettsia are arthropod-borne bacteria which have caused diseases that have had a military impact by sweeping through troops and incapacitating them, such as the so called Trench Fevers of World War I and II. Rickettsia rickettsii is commonly known as Rocky Mountain spotted fever, the most commonly fatal tick-borne disease in the United States. Differentiating rickettsial diseases from other acute tropical febrile illnesses can be difficult because of the similarities in signs and symptoms. This briefing explores the hypothesis that as infection of human monocytes with R. rickettsii causes a specific mRNA expression pattern, this pattern could be used to distinguish different types of infection and to identify novel genes involved in host response.

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Document Details

Document Type
Technical Report
Publication Date
Nov 15, 2004
Accession Number
ADA449539

Entities

People

  • Chien-Chung Chao

Organizations

  • Naval Medical Research Center

Tags

DTIC Thesaurus Topics

  • Diseases And Disorders
  • Dna Microarrays
  • Experimental Design
  • Gram-Negative Bacterial Infections
  • Infection
  • Infectious Diseases
  • Microarray Analysis
  • Monocytes
  • Rickettsial Diseases
  • Rocky Mountains
  • Scrub Typhus
  • Signs And Symptoms
  • Therapy
  • Tickborne Diseases
  • Typhus
  • United States
  • Wound Infections

Readers

  • Breast cancer cell signaling and growth regulation.
  • Infectious Disease/Epidemiology
  • Military History of the United States in the 20th Century.