Breath Analysis Using Photoionization Mass Spectrometry
Abstract
REMPI (Resonantly Enhanced Multi Photon Ionization) is an ultra-sensitive analytical technique based on the unique combination of laser spectroscopy and mass spectrometry that can rapidly identify and quantify vapor-phase constituents present at part per trillion levels. We have used this method to examine human breath samples for biomarkers of infection. Based on the observed results, we estimate our limit of detection for the photoionization system is a factor of 40-100 times lower than we can achieve using the newest GC/MS instrument. Of more importance perhaps, compounds such as benzene, toluene or even dichlorobenzene can readily be detected using this method.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 16, 2004
- Accession Number
- ADA449580
Entities
People
- Harald Oser
- Michael J. Coggiola
- Steve E. Young
Organizations
- SRI International