Volatile Organic Biomarkers in Exhaled Breath as a Rapid, Prodromal, Diagnosis of Bioagent Infection

Abstract

We have studied the feasibility of using biomarkers in exhaled breath as a prodromal diagnostic for bioagent infection. A compact sampling system was developed and used to collect more than 75 breath samples from 9 piglets. Three of the sampled piglets were uninfected control animals, three were infected with staphylococcal enterotoxin B (SEB), and three with Actinobacillus pleuropneumoniae (A.p.). We found that: volatile markers appeared several hours before outwardly noticeable physical symptoms of illness; volatile profiles for infected piglets were distinct from the uninfected animals and room background air samples; and the volatile profiles for SEB and A.p. were different.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Nov 16, 2004
Accession Number
ADA449581

Entities

People

  • Harald Oser
  • Marti Jett
  • Michael J. Coggiola
  • Sachin Mani
  • Steve E. Young

Organizations

  • SRI International

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Alkanes
  • Biological Markers
  • Biological Toxins
  • Burns
  • Detection
  • Diseases And Disorders
  • Environment
  • Fatty Acids
  • Infection
  • Inorganic Carbon Compounds
  • Lymphocytes
  • Metabolic Pathways
  • Metabolism
  • Organic Compounds
  • Wound Infections
  • Wounds And Injuries

Readers

  • Environmental Engineering.
  • Immunology
  • Oncology and Biomarker-Based Cancer Detection.