Adenosine Receptor Agonist Pd 81,723 Protects Against Seizure/Status Epilepticus and Neuropathology Following Organophosphate Exposure
Abstract
A novel approach to broad-specificity medical countermeasure against chemical warfare nerve agent (CWNA) poisoning is by preventing excessive accumulation of ACh attributable to AChE inhibition of CWNA exposure. The effectiveness of various partial adenosine A1 receptor agonists as post-CWNA exposure (1 hour) neuroprotectants was investigated in the study using a rat seizure/status epilepticus model that employs the organophosphate diisopropylfluorophosphate, a surrogate comparable to the nerve agent soman. Physiological data collected via radiotelemetry demonstrates that the adenosine receptor agonist PD 81,723 protects against status epilepticus and neuropathology resulting from DFP exposure and can potentially be used for treatment against CWNA exposure.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 17, 2004
- Accession Number
- ADA449590
Entities
People
- Jaimee R. Compton
- Keith H. Steele
- Madhusoodana P. Nambiar
- Richard K. Gordon
- Ruthie H. Ratcliffe
- Stacy M. Crawford
Organizations
- Walter Reed Army Institute of Research