Heteropolymers: A New Class of Therapeutics for Treating Lethal Bacterial and Viral Infections

Abstract

Heteropolymers (HPs) contain a MAb directed against the Complement Receptor type 1 (CR1) on primate RBCs, chemically cross-linked to MAbs that recognize pathogens. Upon administration of HPs pathogens are bound to the HP and immobilized on RBCs, which move through the circulation to the liver and spleen where the CR1-HP-pathogen complex is phagocytosed and destroyed by tissue macrophages. A unique feature of HPs is that the anti-pathogen MAb can be directed to a nonneutralizing epitope on the target organism. HPs are efficacious in treating lethal bacterial and viral infections and can be used as prophylactic for biowarfare agents.

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Document Details

Document Type
Technical Report
Publication Date
Nov 17, 2004
Accession Number
ADA449597

Entities

People

  • Barry Kreiswirth
  • Claudia Ferreira
  • George L. Spitalny
  • Juan Li
  • Leslie S. Casey
  • Nehal Mohamed
  • Steven E. Pincus
  • Steven M. Jones
  • Xun Chen

Tags

DTIC Thesaurus Topics

  • Bacteria
  • Bacterial Infections
  • Blood
  • Blood Cells
  • Cells
  • Disease Outbreaks
  • Health
  • Immune System
  • Infection
  • Infectious Diseases
  • Poxviridae Infections
  • Proteins
  • Public Health
  • Therapy
  • Virus Diseases
  • Viruses
  • Zoonoses

Fields of Study

  • Biology

Readers

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  • Molecular and Cellular Biochemistry
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