Inflammatory Gene Response in Rat Brain Following Soman Exposure

Abstract

This study reports an upregulation of the neuro-inflammatory gene response using quantitative RT-PCR following soman exposure in rats. Male Sprague-Dawley rats were pre-treated with HI-6 (125 mg/kg, i.p.) and exposed 30 min later to 1.6x LD50 of soman (180 microgram/kg, s.c.) followed at 1 min by atropine (4 mg/kg, i.m.). Initially, a significant upregulation of TNF-alpha and VCAM- 1 mRNA levels were measured 2 h post-exposure followed at 6 h by IL-1BETA, IL-6, E-selection, and ICAM-1 with resolution by 24-48 h. In conclusion, an acute upregulation of the inflammatory gene response is activated following soman exposure and may be involved in soman-induced brain injury.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2005
Accession Number
ADA449664

Entities

People

  • Anthony J. Williams
  • Changping Yao
  • Frank C. Tortella
  • Irwin Koplovitz
  • Jitendra R. Dave
  • Luisa C. Velarde
  • Rebecca A. Prince
  • Rossana Berti
  • Susan M. Shulz

Organizations

  • Walter Reed Army Institute of Research

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Blood-Brain Barrier
  • Brain
  • Brain Injuries
  • Cell Physiological Processes
  • Cells
  • Central Nervous System
  • Diseases And Disorders
  • Gene Expression
  • Hippocampus
  • Immune System
  • Inflammation
  • Molecules
  • Multiple Sclerosis
  • Nerve Agents
  • Poisoning
  • Proteins

Fields of Study

  • Medicine

Readers

  • Immunology and Pathology
  • Neurotoxicology
  • Toxicology/Environmental Toxicology