The Use of a Selenium-Peptide to Specifically Inactivate Yersinia pestis
Abstract
The briefing discusses a project to develop an antibiotic that will selectively kill Yersinia pestis without killing other bacteria, while using a killing mechanism that Y. pestis can not develop a resistance to. This requires a target mechanism to bind to a specific protein on the Y. pestis, leading the researchers to look at peptides. Peptides are less expensive, more stable and easier to deliver than antibodies. The project examined the hypothesis that selenium labeled peptides and selenium labeled bacterial viruses (phage) can be produced that can selectively bind to the surface of a pathogenic bacteria and inactivate them through the generation of superoxide radicals on their surface.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2005
- Accession Number
- ADA449732
Entities
People
- Joe A. Fralick
- Phat Tran
Organizations
- Texas Tech University Health Sciences Center